Ontology highlight
ABSTRACT:
SUBMITTER: Obenauf AC
PROVIDER: S-EPMC3822999 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Obenauf Anna C AC Schwarzbraun Thomas T Auer Martina M Hoffmann Eva M EM Waldispuehl-Geigl Julie J Ulz Peter P Günther Barbara B Duba Hans-Christoph HC Speicher Michael R MR Geigl Jochen B JB
Journal of cellular and molecular medicine 20100801 8
The analysis of structural variants associated with specific phenotypic features is promising for the elucidation of the function of involved genes. There is, however, at present no approach allowing the rapid mapping of chromosomal translocation breakpoints to the basepair level from a single chromosome. Here we demonstrate that we have advanced both the microdissection and the subsequent unbiased amplification to an extent that breakpoint mapping to the basepair level has become possible. As a ...[more]