Ontology highlight
ABSTRACT:
SUBMITTER: Jaber-Hijazi F
PROVIDER: S-EPMC3824064 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Jaber-Hijazi Farah F Lo Priscilla J K P PJ Mihaylova Yuliana Y Foster Jeremy M JM Benner Jack S JS Tejada Romero Belen B Chen Chen C Malla Sunir S Solana Jordi J Ruzov Alexey A Aziz Aboobaker A A
Developmental biology 20130921 1
Planarian adult stem cells (pASCs) or neoblasts represent an ideal system to study the evolution of stem cells and pluripotency as they underpin an unrivaled capacity for regeneration. We wish to understand the control of differentiation and pluripotency in pASCs and to understand how conserved, convergent or divergent these mechanisms are across the Bilateria. Here we show the planarian methyl-CpG Binding Domain 2/3 (mbd2/3) gene is required for pASC differentiation during regeneration and tiss ...[more]