Ontology highlight
ABSTRACT:
SUBMITTER: Chanda S
PROVIDER: S-EPMC3825097 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Chanda Sarmishtha S Dasgupta Uma B UB Mazumder Debendranath Guha DG Saha Jayita J Gupta Bhaskar B
SpringerPlus 20131024
Arsenic, though a poor mutagen, is an accepted environmental carcinogen. Perturbation of DNA methylation pattern leading to aberrant gene expression has been hypothesized as the mechanism for arsenic induced carcinogenesis. We had earlier demonstrated the hypermethylation of promoter region of p53 and p16 genes in persons exposed to different doses of arsenic. Till now no genomic hot spot has been identified which is frequently hypermethylated or hypomethylated in persons chronically exposed to ...[more]