Targeting the Transforming Growth Factor-? Signaling in Cancer Therapy.
Ontology highlight
ABSTRACT:
SUBMITTER: Sheen YY
PROVIDER: S-EPMC3825194 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy.
Sheen Yhun Yhong YY Kim Min-Jin MJ Park Sang-A SA Park So-Yeon SY Nam Jeong-Seok JS
Biomolecules & therapeutics 20130901 5
TGF-β pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-β (TGF-β) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-β related functional contexts. This review discusses the molecular mechanism of the TGF-β pathway and describes the different ways of tumor suppression and promotion by TGF-β. In the last part of the review, the data o ...[more]
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