Unknown

Dataset Information

0

Transforming Growth Factor-? Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts.


ABSTRACT: Transforming growth factor-? (TGF-?) signaling is essential in embryo development and maintaining normal homeostasis. Extensive evidence shows that TGF-? activation acts on several cell types, including epithelial cells, fibroblasts, and immune cells, to form a pro-fibrotic environment, ultimately leading to fibrotic diseases. TGF-? is stored in the matrix in a latent form; once activated, it promotes a fibroblast to myofibroblast transition and regulates extracellular matrix (ECM) formation and remodeling in fibrosis. TGF-? signaling can also promote cancer progression through its effects on the tumor microenvironment. In cancer, TGF-? contributes to the generation of cancer-associated fibroblasts (CAFs) that have different molecular and cellular properties from activated or fibrotic fibroblasts. CAFs promote tumor progression and chronic tumor fibrosis via TGF-? signaling. Fibrosis and CAF-mediated cancer progression share several common traits and are closely related. In this review, we consider how TGF-? promotes fibrosis and CAF-mediated cancer progression. We also discuss recent evidence suggesting TGF-? inhibition as a defense against fibrotic disorders or CAF-mediated cancer progression to highlight the potential implications of TGF-?-targeted therapies for fibrosis and cancer.

SUBMITTER: Shi X 

PROVIDER: S-EPMC7763058 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts.

Shi Xueke X   Young Christian D CD   Zhou Hongmei H   Wang Xiaojing X  

Biomolecules 20201212 12


Transforming growth factor-β (TGF-β) signaling is essential in embryo development and maintaining normal homeostasis. Extensive evidence shows that TGF-β activation acts on several cell types, including epithelial cells, fibroblasts, and immune cells, to form a pro-fibrotic environment, ultimately leading to fibrotic diseases. TGF-β is stored in the matrix in a latent form; once activated, it promotes a fibroblast to myofibroblast transition and regulates extracellular matrix (ECM) formation and  ...[more]

Similar Datasets

| S-EPMC10782472 | biostudies-literature
| S-EPMC7738904 | biostudies-literature
| S-EPMC3825194 | biostudies-literature
| S-EPMC10879340 | biostudies-literature
| S-EPMC2740918 | biostudies-literature
| S-EPMC2796203 | biostudies-literature
| S-EPMC4263601 | biostudies-literature
| S-EPMC5550896 | biostudies-literature
| S-EPMC2640227 | biostudies-other
| S-EPMC6788707 | biostudies-literature