Ontology highlight
ABSTRACT:
SUBMITTER: Ageta-Ishihara N
PROVIDER: S-EPMC3826633 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Ageta-Ishihara Natsumi N Miyata Takaki T Ohshima Chika C Watanabe Masahiko M Sato Yoshikatsu Y Hamamura Yuki Y Higashiyama Tetsuya T Mazitschek Ralph R Bito Haruhiko H Kinoshita Makoto M
Nature communications 20130101
Neurite growth requires two guanine nucleotide-binding protein polymers of tubulins and septins. However, whether and how those cytoskeletal systems are coordinated was unknown. Here we show that the acute knockdown or knockout of the pivotal septin subunit SEPT7 from cerebrocortical neurons impairs their interhemispheric and cerebrospinal axon projections and dendritogenesis in perinatal mice, when the microtubules are severely hyperacetylated. The resulting hyperstabilization and growth retard ...[more]