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Single-round, multiplexed antibody mimetic design through mRNA display.

ABSTRACT: In a single round: By combining the high-efficiency enrichment through the continuous-flow magnetic separation (CFMS) technique with the analytical power of next-generation sequencing, the generation of antibody mimetics with a single round of mRNA display is made possible. This approach eliminates iterative selection cycles and provides a path to fully automated ligand generation (see picture).

SUBMITTER: Olson CA 

PROVIDER: S-EPMC3832244 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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In a single round: By combining the high-efficiency enrichment through the continuous-flow magnetic separation (CFMS) technique with the analytical power of next-generation sequencing, the generation of antibody mimetics with a single round of mRNA display is made possible. This approach eliminates iterative selection cycles and provides a path to fully automated ligand generation (see picture). ...[more]

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