Ontology highlight
ABSTRACT:
SUBMITTER: See K
PROVIDER: S-EPMC8585965 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
See Kyra K Kadonosono Tetsuya T Miyamoto Kotaro K Tsubaki Takuya T Ota Yumi Y Katsumi Marina M Ryo Sumoe S Aida Kazuki K Minegishi Misa M Isozaki Tatsuhiro T Kuchimaru Takahiro T Kizaka-Kondoh Shinae S
Scientific reports 20211111 1
Small antibody mimetics that contain high-affinity target-binding peptides can be lower cost alternatives to monoclonal antibodies (mAbs). We have recently developed a method to create small antibody mimetics called FLuctuation-regulated Affinity Proteins (FLAPs), which consist of a small protein scaffold with a structurally immobilized target-binding peptide. In this study, to further develop this method, we established a novel screening system for FLAPs called monoclonal antibody-guided peptid ...[more]