Ontology highlight
ABSTRACT:
SUBMITTER: Scumpia PO
PROVIDER: S-EPMC3837089 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Scumpia Philip O PO Kelly-Scumpia Kindra M KM Delano Matthew J MJ Weinstein Jason S JS Cuenca Alex G AG Al-Quran Samer S Bovio Ian I Akira Shizuo S Kumagai Yutaro Y Moldawer Lyle L LL
Journal of immunology (Baltimore, Md. : 1950) 20100203 5
Bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) can be activated by type I IFNs, TLR agonists, viruses, and bacteria to increase hematopoiesis. In this study, we report that endotoxin treatment in vivo induces TLR4, MyD88, and Toll/IL-1 resistance domain-containing adaptor-inducing IFN-beta (TRIF)-dependent expansion of BM HSPCs. Bacterial infection by Staphylococcus aureus or cecal ligation and puncture also induces HSPC expansion, but MyD88, TRIF, type I IFN, cytokine, PG, or ...[more]