Ontology highlight
ABSTRACT:
SUBMITTER: Degos V
PROVIDER: S-EPMC3837433 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Degos Vincent V Peineau Stéphane S Nijboer Cora C Kaindl Angela M AM Sigaut Stéphanie S Favrais Géraldine G Plaisant Frank F Teissier Natacha N Gouadon Elodie E Lombet Alain A Saliba Elie E Collingridge Graham L GL Maze Mervyn M Nicoletti Ferdinando F Heijnen Cobi C Mantz Jean J Kavelaars Annemieke A Gressens Pierre P
Annals of neurology 20130314 5
<h4>Objective</h4>The concept of inflammation-induced sensitization is emerging in the field of perinatal brain injury, stroke, Alzheimer disease, and multiple sclerosis. However, mechanisms underpinning this process remain unidentified.<h4>Methods</h4>We combined in vivo systemic lipopolysaccharide-induced or interleukin (IL)-1β-induced sensitization of neonatal and adult rodent cortical neurons to excitotoxic neurodegeneration with in vitro IL-1β sensitization of human and rodent neurons to ex ...[more]