Ontology highlight
ABSTRACT:
SUBMITTER: McClure LV
PROVIDER: S-EPMC3838127 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Journal of virology 20130925 23
3' untranslated regions (UTRs) are known to play an important role in posttranscriptional regulation of gene expression. Here we map the 3' UTRs of Kaposi's sarcoma-associated herpesvirus (KSHV) using next-generation RNA sequencing, 3' rapid amplification of cDNA ends (RACE), and tiled microarray analyses. Chimeric reporters containing the KSHV 3' UTRs show a general trend toward reduced gene expression under conditions of latent infection. Those 3' UTRs with a higher GC content are more likely ...[more]