Ontology highlight
ABSTRACT:
SUBMITTER: Liu N
PROVIDER: S-EPMC3838258 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Liu Ningning N Zhang Jinfang J Jiao Tong T Li Zhiwei Z Peng Jirun J Cui Zhuqingqing Z Ye Xin X
Journal of virology 20131002 24
Hepatitis B virus (HBV) causes chronic hepatitis in hundreds of millions of people worldwide, which can eventually lead to hepatocellular carcinoma (HCC). The molecular mechanisms underlying HBV persistence are not well understood. In this study, we found that HBV inhibited the chemotherapy drug etoposide-induced apoptosis of hepatoma cells. Further analysis revealed that HBV mRNAs possess a microRNA 15a/16 (miR-15a/16)-complementary site (HBV nucleotides [nt] 1362 to 1383) that acts as a sponge ...[more]