Ontology highlight
ABSTRACT:
SUBMITTER: Varadi A
PROVIDER: S-EPMC3839676 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Váradi András A Hosztafi Sándor S Le Rouzic Valerie V Tóth Gergő G Urai Ákos Á Noszál Béla B Pasternak Gavril W GW Grinnell Steven G SG Majumdar Susruta S
European journal of medicinal chemistry 20130922
Aminomorphinans are a relatively young class of opioid drugs among which substances of high in vitro efficacy and favorable in vivo action are found. We report the synthesis and pharmacological evaluation of novel 6β-acylaminomorphinans. 6β-Morphinamine and 6β-codeinamine were stereoselectively synthesized by Mitsunobu reaction. The aminomorphinans were subsequently acylated with diversely substituted cinnamic acids. In vitro binding studies on cinnamoyl morphinamines showed moderate affinity fo ...[more]