Ontology highlight
ABSTRACT:
SUBMITTER: Gordon SC
PROVIDER: S-EPMC3842114 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Gordon Stuart C SC Krastev Zahary Z Horban Andrzej A Petersen Jörg J Sperl Jan J Dinh Phillip P Martins Eduardo B EB Yee Leland J LJ Flaherty John F JF Kitrinos Kathryn M KM Rustgi Vinod K VK Marcellin Patrick P
Hepatology (Baltimore, Md.) 20130503 2
<h4>Unlabelled</h4>We evaluated the antiviral response of patients with chronic hepatitis B (CHB) who had baseline high viral load (HVL), defined as having hepatitis B virus (HBV) DNA ≥ 9 log10 copies/mL, after 240 weeks of tenofovir disoproxil fumarate (TDF) treatment. A total of 641 hepatitis B e antigen (HBeAg)-negative and HBeAg-positive patients (129 with HVL) received 48 weeks of TDF 300 mg (HVL n = 82) or adefovir dipivoxil (ADV) 10 mg (HVL n = 47), followed by open-label TDF for an addit ...[more]