Ontology highlight
ABSTRACT:
SUBMITTER: Mahajan D
PROVIDER: S-EPMC3842536 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Mahajan Divyanshu D Boh Boon Kim BK Zhou Yan Y Chen Li L Cornvik Tobias Carl TC Hong Wanjin W Lu Lei L
Scientific reports 20131128
Arl1 is a member of Arf family small GTPases that is essential for the organization and function of Golgi complex. Mon2/Ysl2, which shares significant homology with Sec7 family Arf guanine nucleotide exchange factors, was poorly characterized in mammalian cells. Here, we report the first in depth characterization of mammalian Mon2. We found that Mon2 localized to trans-Golgi network which was dependent on both its N and C termini. The depletion of Mon2 did not affect the Golgi localized or cellu ...[more]