Ontology highlight
ABSTRACT:
SUBMITTER: Bunse S
PROVIDER: S-EPMC3847041 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Bunse Stefanie S Garg Sakshi S Junek Stephan S Vogel Dirk D Ansari Nariman N Stelzer Ernst H K EH Schuman Erin E
PloS one 20131202 12
Cadherins, Ca(2+)-dependent adhesion molecules, are crucial for cell-cell junctions and remodeling. Cadherins form inter-junctional lattices by the formation of both cis and trans dimers. Here, we directly visualize and quantify the spatiotemporal dynamics of wild-type and dimer mutant N-cadherin interactions using time-lapse imaging of junction assembly, disassembly and a FRET reporter to assess Ca(2+)-dependent interactions. A trans dimer mutant (W2A) and a cis mutant (V81D/V174D) exhibited an ...[more]