Ontology highlight
ABSTRACT:
SUBMITTER: Schmeisser MJ
PROVIDER: S-EPMC3849298 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Schmeisser Michael J MJ Kühl Susanne J SJ Schoen Michael M Beth Nathalie H NH Weis Tobias M TM Grabrucker Andreas M AM Kühl Michael M Boeckers Tobias M TM
Neural development 20130917
<h4>Background</h4>Circuit formation in the nervous system essentially relies on the proper development of neurons and their processes. In this context, the ubiquitin ligase Nedd4 is a crucial modulator of axonal and dendritic branching.<h4>Results</h4>Herein we characterize the Nedd4-binding protein 3 (N4BP3), a Fezzin family member, during nerve cell development. In developing rat primary hippocampal neurons, endogenous N4BP3 localizes to neuronal processes, including axons and dendrites. Tran ...[more]