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Relative and absolute stereochemistry of diacarperoxides: antimalarial norditerpene endoperoxides from marine sponge Diacarnus megaspinorhabdosa.

ABSTRACT: Five new norditerpene endoperoxides, named diacarperoxides H-L (1-5), and a new norditerpene diol, called diacardiol B (6), were isolated from the South China Sea sponge, Diacarnus megaspinorhabdosa. Their structures, including conformations and absolute configurations, were determined by using spectroscopic analyses, computational approaches and chemical degradation. Diacarperoxides H-J (1-3) showed some interesting stereochemical issues, as well as antimalarial activity.

SUBMITTER: Yang F

PROVIDER: S-EPMC4145323 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Relative and absolute stereochemistry of diacarperoxides: antimalarial norditerpene endoperoxides from marine sponge Diacarnus megaspinorhabdosa.

Yang Fan F Zou Yike Y Wang Ru-Ping RP Hamann Mark T MT Zhang Hong-Jun HJ Jiao Wei-Hua WH Han Bing-Nan BN Song Shao-Jiang SJ Lin Hou-Wen HW

Marine drugs 20140808 8

Five new norditerpene endoperoxides, named diacarperoxides H-L (1-5), and a new norditerpene diol, called diacardiol B (6), were isolated from the South China Sea sponge, Diacarnus megaspinorhabdosa. Their structures, including conformations and absolute configurations, were determined by using spectroscopic analyses, computational approaches and chemical degradation. Diacarperoxides H-J (1-3) showed some interesting stereochemical issues, as well as antimalarial activity. ...[more]

PMID: 25110917

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