Ontology highlight
ABSTRACT:
SUBMITTER: Di Palma F
PROVIDER: S-EPMC3851719 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
RNA (New York, N.Y.) 20130919 11
Riboswitches are structured mRNA elements that modulate gene expression. They undergo conformational changes triggered by highly specific interactions with sensed metabolites. Among the structural rearrangements engaged by riboswitches, the forming and melting of the aptamer terminal helix, the so-called P1 stem, is essential for genetic control. The structural mechanisms by which this conformational change is modulated upon ligand binding mostly remain to be elucidated. Here, we used pulling mo ...[more]