Ontology highlight
ABSTRACT:
SUBMITTER: Nozinovic S
PROVIDER: S-EPMC4152369 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
RNA biology 20140612 5
We report here an in-depth characterization of the aptamer domain of the transcriptional adenine-sensing riboswitch (pbuE) by NMR and fluorescence spectroscopy. By NMR studies, the structure of two aptamer sequences with different lengths of the helix P1, the central element involved in riboswitch conformational switching, was characterized. Hydrogen-bond interactions could be mapped at nucleotide resolution providing information about secondary and tertiary structure, structure homogeneity and ...[more]