Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC3855410 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20121220 6121
Cytosolic DNA induces type I interferons and other cytokines that are important for antimicrobial defense but can also result in autoimmunity. This DNA signaling pathway requires the adaptor protein STING and the transcription factor IRF3, but the mechanism of DNA sensing is unclear. We found that mammalian cytosolic extracts synthesized cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP) in vitro from adenosine triphosphate and guanosine triphosphate in the presenc ...[more]