Ontology highlight
ABSTRACT:
SUBMITTER: Gao D
PROVIDER: S-EPMC3860819 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20130808 6148
Retroviruses, including HIV, can activate innate immune responses, but the host sensors for retroviruses are largely unknown. Here we show that HIV infection activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) to produce cGAMP, which binds to and activates the adaptor protein STING to induce type I interferons and other cytokines. Inhibitors of HIV reverse transcriptase, but not integrase, abrogated interferon-β induction by the virus, suggesting that the rev ...[more]