Ontology highlight
ABSTRACT:
SUBMITTER: Collins AC
PROVIDER: S-EPMC4499468 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Cell host & microbe 20150602 6
Activation of the DNA-dependent cytosolic surveillance pathway in response to Mycobacterium tuberculosis infection stimulates ubiquitin-dependent autophagy and inflammatory cytokine production, and plays an important role in host defense against M. tuberculosis. However, the identity of the host sensor for M. tuberculosis DNA is unknown. Here we show that M. tuberculosis activated cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) in macrophages to produce cGAMP, a se ...[more]