Secretory protein profiling reveals TNF-? inactivation by selective and promiscuous Sec61 modulators.
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ABSTRACT:
SUBMITTER: Maifeld SV
PROVIDER: S-EPMC3855466 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators.
Maifeld Sarah V SV MacKinnon Andrew L AL Garrison Jennifer L JL Sharma Ajay A Kunkel Eric J EJ Hegde Ramanujan S RS Taunton Jack J
Chemistry & biology 20110901 9
Cotransins are cyclic heptadepsipeptides that bind the Sec61 translocon to inhibit cotranslational translocation of a subset of secreted and type I transmembrane proteins. The few known cotransin-sensitive substrates are all targeted to the translocon by a cleavable signal sequence, previously shown to be a critical determinant of cotransin sensitivity. By profiling two cotransin variants against a panel of secreted and transmembrane proteins, we demonstrate that cotransin side-chain differences ...[more]
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