Ontology highlight
ABSTRACT:
SUBMITTER: Thavandiran N
PROVIDER: S-EPMC3856835 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Thavandiran Nimalan N Dubois Nicole N Mikryukov Alexander A Massé Stéphane S Beca Bogdan B Simmons Craig A CA Deshpande Vikram S VS McGarry J Patrick JP Chen Christopher S CS Nanthakumar Kumaraswamy K Keller Gordon M GM Radisic Milica M Zandstra Peter W PW
Proceedings of the National Academy of Sciences of the United States of America 20131119 49
Access to robust and information-rich human cardiac tissue models would accelerate drug-based strategies for treating heart disease. Despite significant effort, the generation of high-fidelity adult-like human cardiac tissue analogs remains challenging. We used computational modeling of tissue contraction and assembly mechanics in conjunction with microfabricated constraints to guide the design of aligned and functional 3D human pluripotent stem cell (hPSC)-derived cardiac microtissues that we t ...[more]