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User-Friendly and Parallelized Generation of Human Induced Pluripotent Stem Cell-Derived Microtissues in a Centrifugal Heart-on-a-Chip.


ABSTRACT: IMPACT STATEMENT:With the ultimate goal in tissue engineering of approaching in vivo functionality as closely as possible, organ-on-a-chip (OoC) systems provide unprecedented game-changing opportunities by enabling creation of perfused three-dimensional tissues. Most of the recently developed OoC systems, however, require complex handling steps. Hence, a large gap still exists between technology development and collection of valuable biological data in a standardized medium- or high-throughput manner. The system presented here bridges this gap by providing a user-friendly framework for the parallelized creation of multiple physiologically relevant tissues, which could be applicable in every laboratory without additional equipment.

SUBMITTER: Schneider O 

PROVIDER: S-EPMC6535963 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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User-Friendly and Parallelized Generation of Human Induced Pluripotent Stem Cell-Derived Microtissues in a Centrifugal Heart-on-a-Chip.

Schneider Oliver O   Zeifang Lisa L   Fuchs Stefanie S   Sailer Carla C   Loskill Peter P  

Tissue engineering. Part A 20190501 9-10


<h4>Impact statement</h4>With the ultimate goal in tissue engineering of approaching <i>in vivo</i> functionality as closely as possible, organ-on-a-chip (OoC) systems provide unprecedented game-changing opportunities by enabling creation of perfused three-dimensional tissues. Most of the recently developed OoC systems, however, require complex handling steps. Hence, a large gap still exists between technology development and collection of valuable biological data in a standardized medium- or hi  ...[more]

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