Ontology highlight
ABSTRACT:
SUBMITTER: Wei Q
PROVIDER: S-EPMC3856926 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Wei Qing Q Xu Qingwen Q Zhang Yuxia Y Li Yujie Y Zhang Qing Q Hu Zeng Z Harris Peter C PC Torres Vicente E VE Ling Kun K Hu Jinghua J
Nature communications 20130101
Sensory organelle cilia have critical roles in mammalian embryonic development and tissue homeostasis. Intraflagellar transport (IFT) machinery is required for the assembly and maintenance of cilia. Yet, how this large complex passes through the size-dependent barrier at the ciliary base remains enigmatic. Here we report that FBF1, a highly conserved transition fibre protein, is required for the ciliary import of assembled IFT particles at the ciliary base. We cloned dyf-19, the Caenorhabditis e ...[more]