Ontology highlight
ABSTRACT:
SUBMITTER: Chuang MC
PROVIDER: S-EPMC6504888 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Chuang Mei-Chun MC Lin Shan-Shan SS Ohniwa Ryosuke L RL Lee Gang-Hui GH Su You-An YA Chang Yu-Chen YC Tang Ming-Jer MJ Liu Ya-Wen YW
The Journal of cell biology 20190320 5
Skeletal muscle development requires the cell-cell fusion of differentiated myoblasts to form muscle fibers. The actin cytoskeleton is known to be the main driving force for myoblast fusion; however, how actin is organized to direct intercellular fusion remains unclear. Here we show that an actin- and dynamin-2-enriched protrusive structure, the invadosome, is required for the fusion process of myogenesis. Upon differentiation, myoblasts acquire the ability to form invadosomes through isoform sw ...[more]