Celecoxib-induced cytotoxic effect is potentiated by inhibition of autophagy in human urothelial carcinoma cells.
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ABSTRACT:
SUBMITTER: Huang KH
PROVIDER: S-EPMC3857231 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Celecoxib-induced cytotoxic effect is potentiated by inhibition of autophagy in human urothelial carcinoma cells.
Huang Kuo-How KH Kuo Kuan-Lin KL Ho I-Lin IL Chang Hong-Chiang HC Chuang Yuan-Ting YT Lin Wei-Chou WC Lee Ping-Yi PY Chang Shih-Chen SC Chiang Chih-Kang CK Pu Yeong-Shiau YS Chou Chien-Tso CT Hsu Chen-Hsun CH Liu Shing-Hwa SH
PloS one 20131209 12
Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, can elicit anti-tumor effects in various malignancies. Here, we sought to clarify the role of autophagy in celecoxib-induced cytotoxicity in human urothelial carcinoma (UC) cells. The results shows celecoxib induced cellular stress response such as endoplasmic reticulum (ER) stress, phosopho-SAPK/JNK, and phosopho-c-Jun as well as autophagosome formation in UC cells. Inhibition of autophagy by 3-methyladenine (3-MA), bafilomycin A1 or ATG7 knockdo ...[more]
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