Targeting loop adenines in G-quadruplex by a selective oxirane.
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ABSTRACT:
SUBMITTER: Doria F
PROVIDER: S-EPMC3863998 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Targeting loop adenines in G-quadruplex by a selective oxirane.
Doria Filippo F Nadai Matteo M Folini Marco M Scalabrin Matteo M Germani Luca L Sattin Giovanna G Mella Mariella M Palumbo Manlio M Zaffaroni Nadia N Fabris Daniele D Freccero Mauro M Richter Sara N SN
Chemistry (Weinheim an der Bergstrasse, Germany) 20121204 1
Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated. ...[more]
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