Ontology highlight
ABSTRACT:
SUBMITTER: Delbecq SP
PROVIDER: S-EPMC3865782 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Delbecq Scott P SP Klevit Rachel E RE
FEBS letters 20130120 8
Small Heat Shock Proteins (sHSPs) are a diverse family of molecular chaperones that delay protein aggregation through interactions with non-native and aggregate-prone protein states. This function has been shown to be important to cellular viability and sHSP function/dysfunction is implicated in many diseases, including Alzheimer's and Alexander disease. Though their gene products are small, many sHSPs assemble into a distribution of large oligomeric states that undergo dynamic subunit exchange. ...[more]