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Temperature-activated nucleic acid nanostructures.

ABSTRACT: DNA and poly(N-isopropylacrylamide) are co-assembled onto gold nanoparticles. The DNA sequences can be reversibly exposed or hidden from the polymer surface in response to temperature cues, thereby translating the temperature trigger to the on-off switching of the surface chemistry and function. When exposed by heating (?30 °C), the DNA rapidly hybridizes to complementary strands, and chain-end biotin groups become readily accessible, while at lower temperatures these activities are largely blocked.

SUBMITTER: Zhang K

PROVIDER: S-EPMC3865851 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Temperature-activated nucleic acid nanostructures.

Zhang Ke K Zhu Xiao X Jia Fei F Auyeung Evelyn E Mirkin Chad A CA

Journal of the American Chemical Society 20130916 38

DNA and poly(N-isopropylacrylamide) are co-assembled onto gold nanoparticles. The DNA sequences can be reversibly exposed or hidden from the polymer surface in response to temperature cues, thereby translating the temperature trigger to the on-off switching of the surface chemistry and function. When exposed by heating (∼30 °C), the DNA rapidly hybridizes to complementary strands, and chain-end biotin groups become readily accessible, while at lower temperatures these activities are largely bloc ...[more]

PMID: 24024953

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