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Click and photo-release dual-functional nucleic acid nanostructures.


ABSTRACT: We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery.

SUBMITTER: Valsangkar VA 

PROVIDER: S-EPMC6687541 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Click and photo-release dual-functional nucleic acid nanostructures.

Valsangkar Vibhav A VA   Chandrasekaran Arun Richard AR   Zhuo Lifeng L   Mao Song S   Lee Goh Woon GW   Kizer Megan M   Wang Xing X   Halvorsen Ken K   Sheng Jia J  

Chemical communications (Cambridge, England) 20190729 65


We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery. ...[more]

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