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Draft Genome Sequence of a Multidrug-Resistant New Delhi Metallo-?-Lactamase-1 (NDM-1)-Producing Escherichia coli Isolate Obtained in Singapore.

ABSTRACT: We report the draft genome sequence of a New Delhi metallo-?-lactamase-1 (NDM-1)-positive Escherichia coli isolate obtained from a surgical patient. The assembled data indicate the presence of 3 multidrug resistance plasmids, 1 of which shares 100% identity with an NDM-1 plasmid isolated previously from a nearby hospital, suggesting possible local transmission.

SUBMITTER: Xia E

PROVIDER: S-EPMC3868851 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Draft Genome Sequence of a Multidrug-Resistant New Delhi Metallo-β-Lactamase-1 (NDM-1)-Producing Escherichia coli Isolate Obtained in Singapore.

Xia Eryu E Khong Wei Xin WX Marimuthu Kalisvar K Xu Wenting W Ong Rick Twee-Hee RT Tan Eng Lee EL Krishnan Prabha Unny PU Ang Brenda Sze Peng BS Lye David Chien DC Chow Angela Li Ping AL Teo Yik-Ying YY Ng Oon Tek OT

Genome announcements 20131219 6

We report the draft genome sequence of a New Delhi metallo-β-lactamase-1 (NDM-1)-positive Escherichia coli isolate obtained from a surgical patient. The assembled data indicate the presence of 3 multidrug resistance plasmids, 1 of which shares 100% identity with an NDM-1 plasmid isolated previously from a nearby hospital, suggesting possible local transmission. ...[more]

PMID: 24356827

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Complete Genome Assembly of a Multidrug-Resistant New Delhi Metallo-?-Lactamase 1 (NDM-1)-Producing Escherichia coli Human Isolate from a New Zealand Hospital.

Project description:We report the complete genome of a multidrug-resistant Escherichia coli strain isolated from a New Zealand patient with a history of hospitalization in India. The strain, carrying eight plasmids, harbors chromosome-encoded nfsA and nfsB mutations, which cause nitrofuran resistance, and class C ?-lactamase (bla EC) and plasmid-encoded bla NDM-1, bla CTX-M-15, and bla CMY-6, as well as other antibiotic resistance genes.

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Draft Genome Sequence of a New Delhi Metallo-?-Lactamase (NDM-1)-Producing Providencia stuartii Strain Isolated in Lima, Peru.

Project description:Providencia stuartii is an opportunistic pathogen of the Enterobacteriales order. Here, we report the 4,594,658-bp draft genome sequence of a New Delhi metallo-?-lactamase (NDM-1)-producing Providencia stuartii strain that was isolated from an emergency patient in a private clinic in Lima, Peru.

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Identification of a New Delhi metallo-?-lactamase-4 (NDM-4)-producing Escherichia coli in Italy.

Project description:BACKGROUND: During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with blaNDM-4 gene were investigated. RESULTS: The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and ?-lactams. The strains produced the NDM-4 carbapenemase and the blaNDM-4 gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405). CONCLUSIONS: This is the first report on the emergence of an MDR strain of E.coli producing the NDM-4 MBL in Italy.

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NDM-1 (New Delhi metallo beta lactamase-1) producing Gram-negative bacilli: emergence & clinical implications.

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New Delhi metallo-β-lactamase-producing Enterobacteriaceae, United States.

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Project description: Not available

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Inhibitor discovery of full-length New Delhi metallo-?-lactamase-1 (NDM-1).

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