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Emergence of metallo-?-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia.

ABSTRACT: A multidrug-resistant Escherichia coli isolate recovered in Australia produced a carbapenem-hydrolyzing ?-lactamase. Molecular investigations revealed the first identification of the bla(NDM-1) metallo-?-lactamase gene in that country. In addition, this E. coli isolate expressed the extended-spectrum ?-lactamase CTX-M-15, together with two 16S rRNA methylases, namely, ArmA and RmtB, conferring a high level of resistance to aminoglycosides.

SUBMITTER: Poirel L

PROVIDER: S-EPMC2976126 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia.

Poirel Laurent L Lagrutta Emilie E Taylor Peter P Pham Jeanette J Nordmann Patrice P

Antimicrobial agents and chemotherapy 20100907 11

A multidrug-resistant Escherichia coli isolate recovered in Australia produced a carbapenem-hydrolyzing β-lactamase. Molecular investigations revealed the first identification of the bla(NDM-1) metallo-β-lactamase gene in that country. In addition, this E. coli isolate expressed the extended-spectrum β-lactamase CTX-M-15, together with two 16S rRNA methylases, namely, ArmA and RmtB, conferring a high level of resistance to aminoglycosides. ...[more]

PMID: 20823289

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