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Identification of a New Delhi metallo-?-lactamase-4 (NDM-4)-producing Escherichia coli in Italy.

ABSTRACT: BACKGROUND: During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with blaNDM-4 gene were investigated. RESULTS: The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and ?-lactams. The strains produced the NDM-4 carbapenemase and the blaNDM-4 gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405). CONCLUSIONS: This is the first report on the emergence of an MDR strain of E.coli producing the NDM-4 MBL in Italy.

SUBMITTER: Coppo E

PROVIDER: S-EPMC4060580 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Identification of a New Delhi metallo-β-lactamase-4 (NDM-4)-producing Escherichia coli in Italy.

Coppo Erika E Del Bono Valerio V Ventura Francesco F Camera Marco M Orengo Giovanni G Viscoli Claudio C Marchese Anna A

BMC microbiology 20140607

<h4>Background</h4>During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with blaNDM-4 gene were investigated.<h4>Results</h4>The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and β-lactams. The strains produced the NDM-4 carbapenemase and the blaNDM-4 gene was part of t ...[more]

PMID: 24906230

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