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Copper-catalyzed trifluoromethylation of alkenes with an electrophilic trifluoromethylating reagent.


ABSTRACT: An efficient method for the copper-catalyzed trifluoromethylation of terminal alkenes with an electrophilic trifluoromethylating reagent has been developed. The reactions proceeded smoothly to give trifluoromethylated alkenes in good to excellent yields. The results provided a versatile approach for the construction of Cvinyl-CF3 bonds without using prefunctionalized substrates.

SUBMITTER: Wang XP 

PROVIDER: S-EPMC3869243 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Copper-catalyzed trifluoromethylation of alkenes with an electrophilic trifluoromethylating reagent.

Wang Xiao-Ping XP   Lin Jin-Hong JH   Zhang Cheng-Pan CP   Xiao Ji-Chang JC   Zheng Xing X  

Beilstein journal of organic chemistry 20131125


An efficient method for the copper-catalyzed trifluoromethylation of terminal alkenes with an electrophilic trifluoromethylating reagent has been developed. The reactions proceeded smoothly to give trifluoromethylated alkenes in good to excellent yields. The results provided a versatile approach for the construction of Cvinyl-CF3 bonds without using prefunctionalized substrates. ...[more]

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