Ontology highlight
ABSTRACT:
SUBMITTER: Champagne PA
PROVIDER: S-EPMC3869259 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Champagne Pier Alexandre PA Saint-Martin Alexandre A Drouin Mélina M Paquin Jean-François JF
Beilstein journal of organic chemistry 20131113
Activation of the C-F bond of benzylic fluorides was achieved using 1,1,1-tris(hydroxymethyl)propane (2) as a hydrogen bond-donating agent. Investigations demonstrated that hydrogen bond-donating solvents are promoting the activation and hydrogen bond-accepting ones are hindering it. However, the reaction is best run under highly concentrated conditions, where solvents cannot interfere with the interaction between the organofluorine compound and the triol. Various benzylic fluorides react with s ...[more]