Ontology highlight
ABSTRACT:
SUBMITTER: Leite-Castro J
PROVIDER: S-EPMC5831813 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Leite-Castro João J Beviano Vanessa V Rodrigues Pedro Nuno PN Freitas Renata R
Journal of developmental biology 20160217 1
<i>HoxA</i> genes encode for important DNA-binding transcription factors that act during limb development, regulating primarily gene expression and, consequently, morphogenesis and skeletal differentiation. Within these genes, <i>HoxA11</i> and <i>HoxA13</i> were proposed to have played an essential role in the enigmatic evolutionary transition from fish fins to tetrapod limbs. Indeed, comparative gene expression analyses led to the suggestion that changes in their regulation might have been ess ...[more]