Ontology highlight
ABSTRACT:
SUBMITTER: Whicher JR
PROVIDER: S-EPMC3870462 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Chemistry & biology 20131031 11
Modular type I polyketide synthases (PKSs) are versatile biosynthetic systems that initiate, successively elongate, and modify acyl chains. Intermediate transfer between modules is mediated via docking domains, which are attractive targets for PKS pathway engineering to produce natural product analogs. We identified a class 2 docking domain in cyanobacterial PKSs and determined crystal structures for two docking domain pairs, revealing a distinct class 2 docking strategy for promoting intermedia ...[more]