Ontology highlight
ABSTRACT:
SUBMITTER: Buchholz TJ
PROVIDER: S-EPMC2853223 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Buchholz Tonia J TJ Geders Todd W TW Bartley Frank E FE Reynolds Kevin A KA Smith Janet L JL Sherman David H DH
ACS chemical biology 20090101 1
Bacterial type I polyketide synthases (PKSs) assemble structurally diverse natural products of significant clinical value from simple metabolic building blocks. The synthesis of these compounds occurs in a processive fashion along a large multiprotein complex. Transfer of the acyl intermediate across interpolypeptide junctions is mediated, at least in large part, by N- and C-terminal docking domains. We report here a comprehensive analysis of the binding affinity and selectivity for the complete ...[more]