Ontology highlight
ABSTRACT:
SUBMITTER: Pecorelli A
PROVIDER: S-EPMC3876710 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Pecorelli Alessandra A Leoni Guido G Cervellati Franco F Canali Raffaella R Signorini Cinzia C Leoncini Silvia S Cortelazzo Alessio A De Felice Claudio C Ciccoli Lucia L Hayek Joussef J Valacchi Giuseppe G
Mediators of inflammation 20131212
Rett syndrome (RTT) is mainly caused by mutations in the X-linked methyl-CpG binding protein (MeCP2) gene. By binding to methylated promoters on CpG islands, MeCP2 protein is able to modulate several genes and important cellular pathways. Therefore, mutations in MeCP2 can seriously affect the cellular phenotype. Today, the pathways that MeCP2 mutations are able to affect in RTT are not clear yet. The aim of our study was to investigate the gene expression profiles in peripheral blood lymphomonoc ...[more]