Ontology highlight
ABSTRACT:
SUBMITTER: Thompson ME
PROVIDER: S-EPMC3876896 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20121209 1
Formins are actin-assembly factors that act in a variety of actin-based processes. The conserved formin homology 2 (FH2) domain promotes filament nucleation and influences elongation through interaction with the barbed end. FMNL3 is a formin that induces assembly of filopodia but whose FH2 domain is a poor nucleator. The 3.4-Å structure of a mouse FMNL3 FH2 dimer in complex with tetramethylrhodamine-actin uncovers details of formin-regulated actin elongation. We observe distinct FH2 actin-bindin ...[more]