Ontology highlight
ABSTRACT:
SUBMITTER: Baker JL
PROVIDER: S-EPMC4286494 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20141204 1
Formins catalyze nucleation and growth of actin filaments. Here, we study the structure and interactions of actin with the FH2 domain of budding yeast formin Bni1p. We built an all-atom model of the formin dimer on an Oda actin filament 7-mer and studied structural relaxation and interprotein interactions by molecular dynamics simulations. These simulations produced a refined model for the FH2 dimer associated with the barbed end of the filament and showed electrostatic interactions between the ...[more]