Ontology highlight
ABSTRACT:
SUBMITTER: Abe T
PROVIDER: S-EPMC3881179 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Abe Takayuki T Harashima Ai A Xia Tianli T Konno Hiroyasu H Konno Keiko K Morales Alejo A Ahn Jeonghyun J Gutman Delia D Barber Glen N GN
Molecular cell 20130307 1
How the cell recognizes cytosolic DNA including DNA-based microbes to trigger host-defense-related gene activation remains to be fully resolved. Here, we demonstrate that STING (stimulator of interferon genes), an endoplasmic reticulum translocon-associated transmembrane protein, acts to detect cytoplasmic DNA species. STING homodimers were able to complex with self- (apoptotic, necrotic) or pathogen-related ssDNA and dsDNA and were indispensible for HSV-1-mediated transcriptional activation of ...[more]