Ontology highlight
ABSTRACT:
SUBMITTER: Simic P
PROVIDER: S-EPMC3881428 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Simic Petra P Williams Eric O EO Bell Eric L EL Gong Jing Jing JJ Bonkowski Michael M Bonkowski Michael M Guarente Leonard L
Cell reports 20130411 4
The epithelial-to-mesenchymal transition (EMT) is important for the development of cancer metastases and organ fibrosis, conditions prevalent in aging. Because sirtuins affect the pathology of aging, we tested the effect of SirT1 on EMT. Reduced SIRT1 levels in HMLER breast cancer cells led to increased metastases in nude mice, and the loss of SIRT1 in kidney tubular epithelial cells exacerbated injury-induced kidney fibrosis. SIRT1 reduces EMT in cancer and fibrosis by deacetylating Smad4 and r ...[more]