Ontology highlight
ABSTRACT:
SUBMITTER: Justenhoven C
PROVIDER: S-EPMC3883876 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Justenhoven Christina C Pentimalli Daniela D Rabstein Sylvia S Harth Volker V Lotz Anne A Pesch Beate B Brüning Thomas T Dörk Thilo T Schürmann Peter P Bogdanova Natalia N Park-Simon Tjoung-Won TW Couch Fergus J FJ Olson Janet E JE Fasching Peter A PA Beckmann Matthias W MW Häberle Lothar L Ekici Arif A Hall Per P Czene Kamilla K Liu Janjun J Li Jingmei J Baisch Christian C Hamann Ute U Ko Yon-Dschun YD Brauch Hiltrud H
International journal of cancer 20130730 2
The cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of testosterone. Functional changes in this enzyme may influence endogenous hormone exposure, which has been associated with risk of breast cancer. To assess potential associations between two functional polymorphisms CYP2B6_516_G>T (rs3745274) and CYP2B6_785_A>G (rs2279343) and breast cancer risk, we established a specific matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay. The GENICA breast cancer ca ...[more]