Ontology highlight
ABSTRACT:
SUBMITTER: Engelmann D
PROVIDER: S-EPMC3888194 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Engelmann David D Mayoli-Nüssle Deborah D Mayrhofer Christian C Fürst Katharina K Alla Vijay V Stoll Anja A Spitschak Alf A Abshagen Kerstin K Vollmar Brigitte B Ran Sophia S Pützer Brigitte M BM
Journal of molecular cell biology 20130906 6
Angiogenesis is essential for primary tumor growth and metastatic dissemination. E2F1, frequently upregulated in advanced cancers, was recently shown to drive malignant progression. In an attempt to decipher the molecular events underlying this behavior, we demonstrate that the tumor cell-associated vascular endothelial growth factor-C/receptor-3 (VEGF-C/VEGFR-3) axis is controlled by E2F1. Activation or forced expression of E2F1 in cancer cells leads to the upregulation of VEGFR-3 and its ligan ...[more]