Ontology highlight
ABSTRACT:
SUBMITTER: Dose M
PROVIDER: S-EPMC3890837 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Dose Marei M Emmanuel Akinola Olumide AO Chaumeil Julie J Zhang Jiangwen J Sun Tianjiao T Germar Kristine K Aghajani Katayoun K Davis Elizabeth M EM Keerthivasan Shilpa S Bredemeyer Andrea L AL Sleckman Barry P BP Rosen Steven T ST Skok Jane A JA Le Beau Michelle M MM Georgopoulos Katia K Gounari Fotini F
Proceedings of the National Academy of Sciences of the United States of America 20131226 1
Deregulated activation of β-catenin in cancer has been correlated with genomic instability. During thymocyte development, β-catenin activates transcription in partnership with T-cell-specific transcription factor 1 (Tcf-1). We previously reported that targeted activation of β-catenin in thymocytes (CAT mice) induces lymphomas that depend on recombination activating gene (RAG) and myelocytomatosis oncogene (Myc) activities. Here we show that these lymphomas have recurring Tcra/Myc translocations ...[more]