Ontology highlight
ABSTRACT:
SUBMITTER: Park SM
PROVIDER: S-EPMC3892968 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Park Sun-Mi SM Deering Raquel P RP Lu Yuheng Y Tivnan Patrick P Lianoglou Steve S Al-Shahrour Fatima F Ebert Benjamin L BL Hacohen Nir N Leslie Christina C Daley George Q GQ Lengner Christopher J CJ Kharas Michael G MG
The Journal of experimental medicine 20140106 1
Hematopoietic stem cells (HSCs) are maintained through the regulation of symmetric and asymmetric cell division. We report that conditional ablation of the RNA-binding protein Msi2 results in a failure of HSC maintenance and engraftment caused by a loss of quiescence and increased commitment divisions. Contrary to previous studies, we found that these phenotypes were independent of Numb. Global transcriptome profiling and RNA target analysis uncovered Msi2 interactions at multiple nodes within p ...[more]